James K Hennan Selected Research

1- (2- aminoacetyl)- 4- benzamidopyrrolidine- 2- carboxylic acid

9/2009	GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.
8/2009	Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
6/2009	The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.
4/2009	Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs.

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James K Hennan Research Topics

Disease

8	Thrombosis (Thrombus) 02/2008 - 06/2002
6	Ischemia 09/2009 - 12/2002
6	Infarction (Infarctions) 09/2009 - 12/2002
6	Atrial Fibrillation 08/2009 - 01/2007
4	Myocardial Ischemia (Ischemic Heart Diseases) 09/2009 - 12/2002
4	Myocardial Infarction 10/2007 - 12/2002
3	Ventricular Tachycardia 09/2009 - 06/2006
3	Cardiac Arrhythmias (Arrythmia) 08/2009 - 10/2007
2	Reperfusion Injury 09/2009 - 04/2006
2	Venous Thrombosis (Deep-Vein Thrombosis) 02/2008 - 06/2002
2	Inflammation (Inflammations) 02/2008 - 12/2002
2	Heart Arrest (Cardiac Arrest) 03/2007 - 06/2006
2	Hemorrhage 03/2006 - 08/2005
2	Carotid Artery Thrombosis 07/2003 - 06/2002
1	Ventricular Premature Complexes (Premature Ventricular Contraction) 09/2009
1	Pericarditis 06/2009
1	Cardiomyopathies (Cardiomyopathy) 04/2009
1	Vascular Diseases (Vascular Disease) 02/2008
1	Tachycardia (Tachyarrhythmias) 10/2007
1	Ventricular Fibrillation 03/2007
1	Heart Failure 01/2007
1	Coronary Occlusion 08/2005
1	Vascular Remodeling 11/2003

Drug/Important Bio-Agent (IBA)

7	rotigaptideIBA 08/2008 - 02/2006
4	1- (2- aminoacetyl)- 4- benzamidopyrrolidine- 2- carboxylic acidIBA 09/2009 - 04/2009
4	antiarrhythmic peptide (AAP)IBA 04/2009 - 02/2006
4	Pharmaceutical PreparationsIBA 10/2007 - 07/2002
3	Glycoproteins (Glycoprotein)IBA 03/2006 - 07/2002
2	Carboxylic AcidsIBA 09/2009 - 06/2009
2	pyrrolidineIBA 09/2009 - 06/2009
2	ConnexinsIBA 04/2009 - 01/2007
2	tiplaxtininIBA 08/2005 - 07/2004
2	Plasminogen Activators (Plasminogen Activator)IBA 08/2005 - 11/2003
2	CRL 42796IBA 07/2003 - 07/2002
1	Polyvinyl Chloride (PVC)IBA 09/2009
1	DipeptidesIBA 09/2009
1	hydroxide ionIBA 08/2009
1	AcidsIBA 02/2009
1	P-SelectinIBA 02/2008
1	quinoline-4-carboxylic acidIBA 02/2008
1	2- (4- chlorobenzyl)- 3- hydroxy- 7,8,9,10- tetrahydrobenzo(H)quinoline- 4- carboxylic acidIBA 02/2008
1	Ion Channels (Ion Channel)IBA 10/2007
1	Peptides (Polypeptides)IBA 01/2007
1	Anti-Arrhythmia AgentsIBA 01/2007
1	salicylhydroxamic acid (SHAM)IBA 01/2007
1	Adenosine Triphosphate (ATP)IBA 01/2007
1	Connexin 43 (Connexin43)IBA 06/2006
1	Clopidogrel (Plavix)FDA Link 03/2006
1	von Willebrand FactorIBA 03/2006
1	AlcoholsIBA 02/2006
1	Halothane (Fluothane)FDA Link 02/2006
1	HydrogenIBA 01/2006
1	sabiporideIBA 01/2006
1	SodiumIBA 01/2006
1	Plasminogen Activator Inhibitor 1IBA 08/2005
1	CollagenIBA 08/2005
1	Adenosine Diphosphate (ADP)IBA 08/2005
1	Acetic Acid (Vinegar)FDA LinkGeneric 08/2005
1	Tissue Plasminogen Activator (Alteplase)FDA Link 11/2003
1	C-Reactive ProteinIBA 12/2002
1	Complement System Proteins (Complement)IBA 12/2002
1	N-acetylheparinIBA 12/2002
1	Heparin (Liquaemin)FDA LinkGeneric 12/2002
1	Croton OilIBA 12/2002
1	Fibrinolytic Agents (Antithrombotic Agents)IBA 07/2002
1	intimatanIBA 06/2002
1	Dalteparin (Dalteparin Sodium)FDA Link 06/2002

Therapy/Procedure

2	Oral Administration 08/2009 - 07/2003
1	Resuscitation 03/2007
1	Ligation 02/2006
1	Subcutaneous Injections 12/2002